منابع مشابه
Enteric neurons show a primary cilium
The primary cilium is a non-motile cilium whose structure is 9+0. It is involved in co-ordinating cellular signal transduction pathways, developmental processes and tissue homeostasis. Defects in the structure or function of the primary cilium underlie numerous human diseases, collectively termed ciliopathies. The presence of single cilia in the central nervous system (CNS) is well documented, ...
متن کاملThe importance of a single primary cilium
The centrosome is the main microtubule-organizing center in animal cells, and helps to influence the morphology of the microtubule cytoskeleton in interphase and mitosis. The centrosome also templates the assembly of the primary cilium, and together they serve as a nexus of cell signaling that provide cells with diverse organization, motility, and sensory functions. The majority of cells in the...
متن کاملSignaling through the Primary Cilium
The presence of single, non-motile "primary" cilia on the surface of epithelial cells has been well described since the 1960s. However, for decades these organelles were believed to be vestigial, with no remaining function, having lost their motility. It wasn't until 2003, with the discovery that proteins responsible for transport along the primary cilium are essential for hedgehog signaling in...
متن کاملThe primary cilium at a glance.
This article is part of a Minifocus on cilia and flagella. For further reading, please see related articles: ‘Sensory reception is an attribute of both primary cilia and motile cilia’ by Robert A. Bloodgood (J. Cell Sci. 123, 505-509), ‘The perennial organelle: assembly and disassembly of the primary cilium’ by E. Scott Seeley and Maxence V. Nachury (J. Cell Sci. 123, 511-518), ‘Flagellar and c...
متن کاملPrimary Cilium-Dependent Signaling Mechanisms
Primary cilia are hair-like organelles and play crucial roles in vertebrate development, organogenesis, health, and many genetic disorders. A primary cilium is a mechano-sensory organelle that responds to mechanical stimuli in the micro-environment. A cilium is also a chemosensor that senses chemical signals surrounding a cell. The overall function of a cilium is therefore to act as a communica...
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2013
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2013.04.011